前列腺癌中雄激素受体的表观遗传学研究进展.pdf

中国肿瘤临床2014 年第41 卷第16期 ChinJClinOncol2014, Vol. 41, No. 16 1057 · · 国家基金研究进展综述 前列腺癌中雄激素受体的表观遗传学研究进展* 尚芝群 马 媛 田 晶 韩瑞发 牛远杰 摘要 雄激素受体（androgen receptor ，AR ）作为核内转录因子是前列腺癌中最常见的治疗靶标，在去势抵抗性前列腺癌 （castration resistant prostate cancer ，CRPC）中雄激素受体也起到了非常重要的作用。去势抵抗性前列腺癌的发生发展机制是当前 的研究热点。表观遗传学的改变在前列腺癌的发展中具有重要作用。甲基化、乙酰化及非编码RNA 可以通过对雄激素受体信号 通路的调控促进或者抑制前列腺癌的发生发展。本文将近期关于前列腺癌雄激素受体信号通路表观遗传学的调节机制进行 综述。 关键词 雄激素受体 表观遗传学 超甲基化 去势抵抗性前列腺癌 doi:10.3969/j.issn. 1000-8179 Epigenetic regulation of androgen receptors in prostate cancer Zhiqun SHANG, Yuan MA, Jing TIAN, Ruifa HAN, Yuanjie NIU Correspondence to: Yuanjie NIU; E-mail: niuyuanjie9317@163.com Department of Surgical Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin Key Laboratory of Urology Based Medicine, Tianjin 300211, China This work was supported by the National Natural Science Foundation of China Youth Project (No and Na- tional Special Project for International Cooperation in Science and Technology (No.2012DFG32220) Abstract The androgen receptor (AR), a nuclear hormone and transcription factor, is the most therapeutic relevant target in pros- tate cancer (PCa) and in the castration-resistant prostate cancer (CRPC). Significant efforts have been focused on understanding the mechanisms involved in the development and progression of CRPC. Recent work has revealed the importance of epigenetic events in- cluding the regulation of AR signaling by methylation, acetylation, and non-coding RNA in the tumorigenesis and development of PCa. We summarize recent findings on the mechanisms of epigenetic regulation of AR signaling in PCa. Keywords