英文溶血性贫血徐运孝PPT.ppt

（一）Get rid of the etiology,  treat the underlying  disease， （二）End hemolysis1、Glucocorticoid2、Immunosuppressive agents3、Plasma exchange4、Dextran （三）Correct anemia1、Compenont transfusion.Correct anemia and  ameliorate symptoms ,reduce the production of abnormal red  cells,relieve outside marrow  hematopoiesis,prevent bone changes and physical retardation2、Other drugs stimulating hematopoiesis （四）Splenectomy （五）Correct defect 1、Allo-BMT 2、Gene therapy 徐运孝 内科学多媒体教案 HEMOLYTIC ANEMIAS 一、General Information ● Hb Structure ● Definition of Hemolytic Anemias 1、Hb StructureH bA（ ?2 ?2） H bA2（ ?2 ?2）H bF （ ?2 ?2 ） Protoporphyrin HematinH b Fe ?2  Haptoglobin non-?2 2、Definition of Hemolytic Anemias Hemolytic anemia is one kind of anemia in which the destruction of red cell is increased while the compensatory function of marrow hematopoisis is insufficient 。Hemolytic disordersHemolytic jaundice 二、Classification and Pathogenesis1、Hemolytic sites: Extravascular hemolysis  Intravascular hemolysis  Hemolysis in situ2、Hereditary Tendency: Hereditary  Acquired 四、Diagnosis （一）Dominant evidence of diagnosis 1、Clinical manifestations of hemolytic anemia 2、Laboratory examinations show the life span of red cells is shortened and the destruction of red cells is excessive. 3、Significant increase of normoblast hyperplasia in bone marrow （二）Distinguish whether there is hemolytic anemia or not1、Evidence of excessive destruction of red cells （1）Examinations about the shortened  life span and the excessive destruction of the red cells. （2） Evidence of the improved free hemoglobin level. （3）Examinations about the abnormal