DNA甲基化修饰异常与肺癌.pdf

29 5 http: / /www. gjbl. net Vol. 29 No. 5 2009 10 International Journal ofPathology and C linical edicine Oct. 2009 DNA 胡春燕 综述 周建华 审校 (中南大学基础医学院病理学系, 长沙 410078) [] DNA 甲基化是表观遗传学研究的重要内容之一, 与多种 瘤的发生发展密切相关近年研究发 现, 肺癌相关基因高甲基化及甲基化转移酶的表达异常与肺癌发生有重要关系了解 DNA 甲基化修饰异常在肺 癌发生机制中的作用, 将有助于患者的早期预防早期诊断和改善预后 [] DNA 甲基化; DNA 甲基转移酶; 肺癌; 去甲基化 [] R734. 2 [] A [ ] 2009) Abnorm ality of DNA m ethylation m odification and lung cancer HU Chunyan, ZHOU Jianhua (D ep artm ent of P athology, B as icM edical C ollege, C en tral S ou th Universi ty, Changsha 410078, Ch ina ) [ Ab stract] DNA methylation is one of the mi portant contents in epigenetics research and it is closely related to the occurrence and the development of various tumors. Recent research found that the hypermethylation of lung cancerrelated genes and the abnormal expression of methyltransferase were closely related to the occurrence of lung cancer. Understanding the role of the abnormalDNA methylation in lung cancerpathogenesis is beneficial to early prevention and diagnosis aswell as the mi provement of prognosis for diseases. [ Key w ord s] DNA methylation; DNA methyltransferase; gene; demethylation [ Int J PatholClin ed, 2009, 29(5): 039805] Ts), 5 [ 12] 50% , 3 CpG [ 1] , 15% DN Ts DNA , DN Ts DN T1, DN T2, DN T3a DN T3b 4DN T1 , 19p12 ~ 13 DNA, DN T1 N 40, ( proliferating cell nuclear antigen, PC