biological properties of iron oxide nanoparticles for cellular and molecular magnetic resonance imaging生物学性质的氧化铁纳米颗粒细胞和分子磁共振成像.pdf

Int. J. Mol. Sci. 2011, 12, 12-23; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Biological Properties of Iron Oxide Nanoparticles for Cellular and Molecular Magnetic Resonance Imaging 1 1 2 2 3 Thomas Schlorf , Manuela Meincke , Elke Kossel , Claus-Christian Glüer , Olav Jansen and Rolf Mentlein 1,* 1 Department of Anatomy, Christian-Albrechts-University Kiel, Otto-Hahn-Platz 8, 24118 Kiel, Germany; E-Mails: thomas.schlorf@gmx.de (T.S.); m.meincke@anat.uni-kiel.de (M.M.) 2 Department of Radiology, Division of Medical Physics, University Clinic Schleswig-Holstein, Campus Kiel, Arnold Heller Straße 9, 24105 Kiel, Germany; E-Mails: ekossel@ifm-geomar.de (E.K.); ccglueer@web.de (C.-C.G.) 3 Department of Neuroradiology, University Clinic Schleswig-Holstein, Campus Kiel, Schittenhelmstraße 10, 24105 Kiel, Germany; E-Mail: o.jansen@neurorad.uni-kiel.de * Author to whom correspondence should be addressed; E-Mail: rment@anat.uni-kiel.de; Tel.: +49-431-880-2460; Fax: +49-431-880-1557. Received: 14 October 2010; in revised form: 9 December 2010 / Accepted: 21 December 2010 / Published: 23 December 2010 Abstract: Superparamagnetic iron-oxide particles (SPIO) are used in different ways as contrast agents for magnetic resonance imaging (MR