common variation in vitamin d pathway genes predicts circulating 25-hydroxyvitamin d levels among african americans维生素d通路基因的常见变异预测循环非洲裔美国人的25 -羟基维生素d浓度.pdf

Common Variation in Vitamin D Pathway Genes Predicts Circulating 25-Hydroxyvitamin D Levels among African Americans 1,2 2 2 2 3 2 Lisa B. Signorello *, Jiajun Shi , Qiuyin Cai , Wei Zheng , Scott M. Williams , Jirong Long , Sarah S. 1 2 4 5 1,2 Cohen , Guoliang Li , Bruce W. Hollis , Jeffrey R. Smith , William J. Blot 1 International Epidemiology Institute, Rockville, Maryland, United States of America, 2 Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine and the Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States of America, 3 Division of Human Genomics, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America, 4 Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, United States of America, 5 Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America Abstract Vitamin D is implicated in a wide range of health outcomes, and although environmental predictors of vitamin D levels are known, the genetic drivers of vitamin D status remain to be clarified. African Americans are a group at particularly high risk for vitamin D insufficiency but to date have been virtually absent from studies of genetic predictors of circulating vitamin D levels. Within the Southern Community Cohort Study, we investigated the association between 94 single nucleotide polymorphisms (SNPs) in five vitamin D pathway genes (GC, VDR, CYP2R1, CYP24A