ehrlichia chaffeensis downregulates surface toll-like receptors 24, cd14 and transcription factors pu.1 and inhibits lipopolysaccharide activation of nf-κb, erk 12 and p38 mapk in host monocytes.pdf

Blackwell Science, LtdOxford, UKCMICellular Microbiology1462-5814Blackwell Publishing Ltd, 20036 Original Article 2175186 E. chaffeensis inhibits TLR-mediated monocyte activationM. Lin and Y. Rikihisa Cellular Microbiology (2004) 6(2), 175–186 doi:10.1046/j.1462-5822.2003.00355.x Ehrlichia chaffeensis downregulates surface Toll-like receptors 2/4, CD14 and transcription factors PU.1 and kk inhibits lipopolysaccharide activation of NF-kkB, ERK 1/2 and p38 MAPK in host monocytes Mingqun Lin and Yasuko Rikihisa* Introduction Department of Veterinary Biosciences, 1925 Coffey Road, Ehrlichia chaffeensis, an obligatory intracellular Gram- The Ohio State University, Columbus, OH 43210, USA. negative bacterium in the family Anaplasmataceae, causes a febrile systemic disease called human mono- Summary cytic ehrlichiosis (HME). As E. chaffeensis exclusively infects and multiplies inside monocytes or macrophages, Microbial ligands, such as lipopolysaccharide (LPS), it is important for E. chaffeensis not to activate bactericidal activate Toll-like receptors (TLRs) of mononuclear