血脂、脂蛋白相关磷脂酶A与糖尿病视网膜病变关系的研究进展[权威资料].doc

血脂、脂蛋白相关磷脂酶A2与糖尿病视网膜病变关系的研究进展 　　[摘要] 糖尿病视网膜病变（DR）是导致不可逆性盲的重要原因之一，DR发病与动脉粥样硬化密切相关，其治疗干预靶点成为当今研究的热点。血浆脂蛋白相关磷脂酶A2（Lp-PLA2）是一种新型的动脉粥样硬化性炎性标志物，与血脂密切相关，由Lp-PLA2所引起的慢性炎症反应与脂质代谢紊乱共同作用导致了动脉粥样硬化的发生。目前，关于Lp-PLA2的认识还不完善，仍需要进行大量的实验研究以明确Lp-PLA2与DR发生、发展的关系及其致病机制。 　　[关键词] 糖尿病视网膜病变；脂蛋白相关磷脂酶A2；动脉粥样硬化；血脂 　　[] R587.2 [] A [] 1674-4721（2016）02（a）-0017-03 　　Research progress of the relationship between blood lipid，lipoprotein-associated phospholipase A2 and diabetic retinopathy 　　ZHU Hong-yun1 JU Hai-bing2▲ 　　1.Clinical College of Kunming General Hospital of Chengdu Military Region of Kunming Medical University，Kunming 650032，China；2.Department of Endocrinology，Kunming General Hospital of Chengdu Military Region，Kunming 650032，China 　　[Abstract] Diabetic retinopathy （DR） is one of the major causes of irreversible blindness，and the onset of DR is closely linked to atherosclerosis.The therapeutic intervention targets for DR has become a research hotspot.As one of novel markers of inflammation in atherosclerosis，lipoprotein-associated phospholipase A2 （Lp-PLA2） is closely related to blood lipid level.The chronic inflammatory reaction caused by Lp-PLA2 combined with lipid metabolism disorders lead to the occurrence of atherosclerosis.Currently，understanding of the Lp-PLA2 is still not perfect，still requires extensive study to make clear that the relationship between Lp-PLA2 and the occurrence and development of DR as well as its pathogenetic mechanism. 　　[Key words] Diabetic retinopathy；Lipoprotein-associated phospholipase A2；Atherosclerosis；Blood lipid 　　在全球由于眼部疾患致盲的3700万患者中，糖尿病视网膜病变（diabetic retinopathy，DR）占4.8%，是导致不可逆性盲的重要原因之一[1]，因而成为近年来备受关注的研究热点。已有研究[2]显示，新诊断2型糖尿病（type 2 diabetes mellitus，T2DM）的DR发生与早期动脉粥样硬化密切相关。也有研究显示，糖尿病微血管和大血管并发症具有相同的发病机制，动脉粥样硬化在糖尿病大血管病变和微血管病变的发病中均起重要作用[3]。血清脂蛋白相关磷脂酶A2（lipoprotein-associated phospholipase A2，Lp-PLA2）是一种新型的动脉粥样硬化性炎性标志物，与血脂密切相关。国外研究[4]显示，新诊断T2DM患者空腹血浆Lp-PLA2水平明显升高，Lp-PLA2是糖尿病患者广泛动脉粥样硬化的一个独立危险因素，这与林秀红等[5]的报道一致。本文就近年来