attenuated response of aged mice to respiratory francisella novicida is characterized by reduced cell death and absence of subsequent hypercytokinemia减毒的反应在小鼠呼吸道弗朗西斯氏菌属novicida特点是减少细胞死亡和缺乏后续hypercytokinemia.pdf

Attenuated Response of Aged Mice to Respiratory Francisella novicida Is Characterized by Reduced Cell Death and Absence of Subsequent Hypercytokinemia 1 2 1 2 2 2 Chris A. Mares , Jyotika Sharma , Sandra S. Ojeda , Qun Li , Jocelyn A. Campos , Elizabeth G. Morris , Jacqueline J. Coalson3, Judy M. Teale1,2* 1 Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America, 2 South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, United States of America, 3 Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America Abstract Background: Pneumonia and pulmonary infections are major causes of mortality among the growing elderly population. Age associated attenuations of various immune parameters, involved with both innate and adaptive responses are collectively known as immune senescence. These changes are likely to be involved with differences in host susceptibility to disease between young and aged individuals. Methodology/Principal Findings: The objective of this study was to assess potential age related differences in the pulmonary host response in mice to the Gram-negative respiratory pathogen, Francisella novicida. We intranasally infected mice with F. novicida and compared various immune and pathological parameters of the pulmonary host response in both young and aged mice. Conclusions/Significance: We observed that 20% of aged mice were able to survive an intranasal challenge with F. novicida wh