as03 adjuvanted ah1n1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in finlandas03佐剂ah1n1疫苗相关的突然增加,童年在芬兰嗜睡症的发病率.pdf

AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland 1 1 2 1 3 Hanna Nohynek *, Jukka Jokinen , Markku Partinen , Outi Vaarala , Turkka Kirjavainen , 1 4 5 6 ¨ ´ 7 ¨ ¨ Jonas Sundman , Sari-Leena Himanen , Christer Hublin , Ilkka Julkunen , Paivi Olsen , Outi Saarenpaa- ¨ 8, Terhi Kilpi1 Heikkila 1 Department of Vaccines and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland, 2 Helsinki Sleep Clinic, Vitalmed Research Centre, Helsinki, Finland, 3 Department of Pediatrics, Children’s Hospital, Helsinki University Hospital, Helsinki, Finland, 4 Department of Clinical Neurophysiology, Tampere University Hospital, Tampere, Finland, 5 Finnish Institute of Occupational Health, Helsinki, Finland, 6 Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki, Finland, 7 Department of Child Neurology, Oulu University Hospital, Oulu, Finland, 8 Department of Pediatrics, Tampere University Hospital, Tampere, Finland Abstract Background: Narcolepsy is a chronic sleep disorder with strong genetic predisposition causing excessive daytime sleepiness and cataplexy. A sudden increase in childhood narcolepsy was observed in Finland soon after pandemic influenza epidemic and vaccination with ASO3-adjuvanted Pandemrix. No increase was observed in other age groups. Methods: Retrospective cohort study. From January 1, 2009 to December 31, 2010 we retrospectively followed the cohort of all children living in Finland and born from January 1991 through December 2005. Vaccination data of the wh