尿液中膀胱肿瘤标志物检测的研究进展.pdf

中国癌症杂志 2009年第19卷第7期 《 》 CHINA ONCOLOGY 2009 Vol.19 No.7 557 尿液中膀胱肿瘤标志物检测的研究进展 杨国良 综述　薄隽杰 审校 上海交通大学医学院附属仁济医院泌尿外科，上海 200127 　　［摘要］　膀胱癌是泌尿系统最常见的恶性肿瘤之一，易复发，发病率正逐年增高。目前膀胱镜检查和尿 细胞学检查仍是膀胱移行细胞癌（bladder transitional cell carcinoma，BTCC）诊断和随访的金标准。由 于膀胱镜检查会带给患者创伤且检测费用昂贵，同时细胞学检查的敏感性低。随着分子生物学技术的发展，许 多膀胱肿瘤标志物被逐步发现，因此选择高敏感性和特异性的膀胱肿瘤标志物用于肿瘤的早期诊断和治疗将具 有重要的临床应用价值。本文就近年来膀胱肿瘤标志物检测的研究进展作一综述。 　　 ［关键词］　膀胱肿瘤；　肿瘤标记物；　肿瘤；　诊断 　　中图分类号：R737.14　　文献标识码：A　　文章编号：1007-3639(2009)07-0557-05 Advancement in bladder cancer markers in urine 　YANG Guo-liang,BO Juan-jie (Department of Urology,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China) Correspondence to：BO Juan-jie　E-mail：bojuanjie@ 　　［Abstract ］ Bladder cancer is a common type of tumor in the urinary system. Its incidence has been increasing and the disease has a high rate of recurrence. Cystoscopy and cytology are the main methods for the diagnosis and the early detection of recurrence for bladder transitional cell carcinoma. Since cystoscopy is expensive and invasive, and although cytology is non-invasive but it is not very sensitive, many tumor makers have recently been studied in the diagnosis of the disease. So how to choose tumor makers with high sensitivity and specificity for the diagnosis of the disease so that the patients with bladder cancer could be treated at the earliest stages is important, the biomarkers may play a very important role in clinical application. In this review we discussed the development of biomarkers for bladder cancer. Key words bladder cancer; tumor makers; neoplasm; diagnosis 　［ ］　 　　膀胱癌是泌尿系统最常见的恶性肿瘤之 1　理想的尿液膀胱肿瘤标记物　理想的BTCC 一，大多是膀胱移行细胞癌（bladder transitional