细胞分子生物学 第 4 章 核酸教学.ppt

4 BASIC MOLECULAR GENETIC MECHANISMS 4.1 Structure of Nucleic Acids 4.2 Transcription of Protein-Coding Genes Formation of Functional mRNA (m7Gppp) 4.3 Control of Gene Expression in Prokaryotes 4.4 The Three Roles of RNA in Translation 4.5 Stepwise Synthesis of Proteins on Ribosomes 4.6 DNA Replication DNA Replication Fork bidirectional growth of both daughter strands 4.7 Viruses: Parasites of the Cellular Genetic System * 成纤维细胞纤连蛋白肝细胞纤连蛋白 CAP:catabolite activator protein分解代射产物激活蛋白质 lac repressor:乳糖操纵子阻遏蛋白 Pol-σ70:RNA polymerase-70 complex核糖核酸聚合酶σ70复合物 eIF：Eukaryotic initiation factors真核起始因子 EF：elongation factors延伸因子 eRF：Eukaryotic release factor真核释放因子 large T-antigen： 解开复制叉附近的DNA双链； Pol α：DNA polymerase α 在RNA引物后形成一段DNA引物，进行复制 Polδ: DNA polymeraseδ (DNA聚合酶δ) Rfc： replication factor C (复制因子C) PCNA： proliferating cell nuclear antigen (增殖细胞核抗原) 使PCNA-Rfc–Polδ复合物从模板上分离 RPA: replication protein A(复制蛋白A) 使核苷酸单链保持适当的构象便于复制 *