Her2过表达与乳腺癌治疗的相关性研究进展_刘尧.pdf

·182· MODERNONCOLOGY, Jan.2010, VO.I18, NO.01 Her2过表达与乳腺癌治疗的相关性研究进展 1, 2 1 1 刘　尧 ,刘文超, 陶玉荣 TherelationbetweenoverexpressionofHer2 andthetherapyofbreastcancer 1, 2 1 1 LIUYao, LIUWen-chao, TAOY-rong 1 DepartmentofClinicalOncology, StateKeyDisciplineofCellBiology, XijingHospita,lTheForthMilitaryMedicalUniversity, Xian 2 710032, China;MedicalOncologyofBaojiCentralHospital, Baoji7 21008, China. 【Abstract】Her2 oncogenecanenhancetheinvasivepotentialofcancercellsbyinhibitingapoptosisandp-regla- tingtheexpressionofVEGF.Itisoverexpressedin20%-30% ofbreastcance,randtheover-expressionofHer2 is anegativemarkerfortheprognosisofbreastcance.rAsanmiportantbiomarkerofbreastcance,rHer2 isalsoancr- cialtherapetictargetinoverexpressedbreastcance.rThisarticlereviewedthelateststdiesabottherelationbe- tweenoverexpressionofHer2 geneandthetherapyofbreastcance.r 【Keywords】breastcance;rHer2;overexpression;therapy ModernOncology2010, 18(0 1):0182-0 184 【】Her2 、(VEGF), Her2 20%-30%, Her2, Her2 , , 。Her2 。 【】;Her2;; 【】R736.3　　　【】A　　　【】167 2-4992-(20 10 )01-0 182-03 　　, -2 ) [1] 120 , 54 , , 、、, 50 。 , 。 Her2 111/10 , 2007 46.5 , Her2 Hercep- 。 tin(, p185) , 2005 24.8/10 , Her2 /ne , 1/4 [2] , 4 8164 ;2000 2005 , 。 3 8.5%。 200 8 3 8, Her2 , , 、, , 。 , 50 /