非布司他规范化治疗慢性肾病伴高尿酸血症的临床效果观察.pdf

医疗医务标准化 非布司他规范化治疗慢性肾病伴高尿酸血症的 临床效果观察 ■ 王 莹 徐 晶 （蚌埠医学院第一附属医院 肾病科） 摘 要： 目的：研究非布司他规范化治疗慢性肾病伴高尿酸血症的临床效果。方法：选取蚌埠医学院第一附属医院肾病科于 2021年2月至2022年6月收治的慢性肾病伴高尿酸血症患者60例，对照组（30例）和观察组（30例），对照组采用苯溴马隆治 疗，观察组采用非布司他规范化治疗。结果：观察组总有效率为93.33%，高于对照组（P＜0.05）。观察组尿酸水平低于对照 组，对比结果差异显著（P＜0.05）。非布司他规范化治疗下慢性肾病伴高尿酸血症患者超敏C反应蛋白低于苯溴马隆治疗， P＜0.05）。非布司他规范化治疗下慢性肾病伴高尿酸血症患者血肌酐 而胎球蛋白A高于苯溴马隆治疗，对比结果差异显著（ 低于苯溴马隆治疗，而肾小球滤过率高于苯溴马隆治疗，对比结果差异显著（P＜0.05）。非布司他规范化治疗下慢性肾病伴 高尿酸血症患者肿瘤细胞因子α、白细胞介素6，分别低于苯溴马隆治疗，对比结果差异显著（P＜0.05）。非布司他规范化 P 治疗下慢性肾病伴高尿酸血症患者恶心、瘙痒、腹泻总发生率为6.67%，低于苯溴马隆治疗的23.33%，对比结果差异显著（ ＜0.05）。结论：非布司他规范化治疗慢性肾病伴高尿酸血症的临床效果显著优于苯溴马隆治疗，因此非布司他规范化治疗 更具推广价值。 关键词：非布司他，慢性肾病，高尿酸血症，肾功能指标 DOI编码：10.3969/j.issn.1002-5944.2023.20.050 Clinical Observation of Febuxostat Standardized Treatment of Chronic Kidney Disease with Hyperuricemia WANG Ying XU Jing Department of Nephrology, the First Affi liated Hospital of Bengbu Medical College Abstract: Objective: To study the clinical effect of febuxostadat standardized treatment of chronic kidney disease with hyperuricemia. Methods: A total of 60 patients with chronic kidney disease accompanied by hyperuricemia admitted to the Department of Nephrology, the First Affi liated Hospital of Bengbu Medical College from February 2021 to June 2022 were selected and divided into the control group (30 cases) and the observation group (30 cases). The control group was treated with benzbromarone, and the observation group was treated with febuxostatin. Results: The