bilateral fronto-parietal integrity in young chronic cigarette smokers a diffusion tensor imaging study双边顶正直年轻慢性吸烟者扩散张量成像研究.pdf

Bilateral Fronto-Parietal Integrity in Young Chronic Cigarette Smokers: A Diffusion Tensor Imaging Study 1 1 1 2 1 1 1 Yanhui Liao , Jinsong Tang , Qijian Deng , Yongwen Deng , Tao Luo , Xuyi Wang , Hongxian Chen , 1 1 3,4 1 Tieqiao Liu , Xiaogang Chen , Arthur L. Brody *, Wei Hao * 1 Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China, 2 Department of Neurosurgery, People’s Hospital of Hunan Province, Changsha, People’s Republic of China, 3 Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America, 4 Departments of Psychiatry and Research, Greater Los Angeles VA Healthcare System, Los Angeles, California, United States of America Abstract Background: Cigarette smoking continues to be the leading cause of preventable morbidity and mortality in China and other countries. Previous studies have demonstrated gray matter loss in chronic smokers. However, only a few studies assessed the changes of white matter integrity in this group. Based on those previous reports of alterations in white matter integrity in smokers, the aim of this study was to examine the alteration of white matter integrity in a large, well-matched sample of chronic smokers and non-smokers. Methodology/Principal Findings: Using in vivo diffusion tensor imaging (DTI) to measure the differences of whole-brain white matter integrity between 44 chronic smoking subjects (mean age, 28.065.6 years) and 44 healthy age- and sex-matched comparison non-smoking volunteers (me