2008埃索美拉唑静脉滴注治疗非静脉曲张性上消化道出血的疗效观察.pdf

埃索美拉唑静脉滴注治疗非静脉曲张性上消化 道出血的疗效观察 * # 孟 莹 , 梁晓梅, 周巧直, 李文燕, 王青 , 吴咏冬, 张澍田 ( 首都医科大学附属北京友谊医 消化内科, 北京 市 100050) + R973 11 B 1672- 2124( 2008) 11- 0851- 03 目的:评估埃索美拉唑40 mg 静脉注射治疗急性非静脉曲张性上消化道出血的疗效和安全方 : 对内镜证实的25例 急性非静脉曲张性上消化道出血征象的患者, 随机双盲分为埃索美拉唑组(n= 19) 和奥美拉唑组(n= 6) , 实验组和对照组分别给 予埃索美拉唑和奥美拉唑40 mg q12 h 静脉滴注, 治疗5 d观察72 h 及120 h 的临床止血疗效及药物不良事件结果: 治疗 72 h 两组临床上无消化道出血征象受试者百分率无显著性差异( P 0105) 治疗120 h 有效率两组均为100% 中位止血时间埃索美 拉唑组为41 h, 奥美拉唑组为20 h, 两组比较无显著性差异( P 0105) 不良事件发生情况两组相似, 均无与药物有关的严重不良 事件发生结论: 静脉给予埃索美拉唑治疗急性非静脉曲张性上消化道出血疗效不劣于奥美拉唑, 和奥美拉唑相比也有很好的耐 受性 质子泵抑制剂; 上消化道出血; 治疗 Clinical Evaluation of Esomeprazole for Patients with Non-variceal Upper Gastrointestinal Bleeding * M NG Ying , LIANG Xiao-mei, ZHOU Qiao-zhi, LI Wen-yan, WANG Qing-gang, WU Yong-dong, # ZHANG Shu-tian ( Dept. of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China) ABST ACT OBJ CTIV : To evaluate the therapeutic efficacy and safety of someprazole (40 mg i. v) in patients with acute upper gastrointestinal bleeding. M THODS: 25 patients with signs of upper gastrointestinal bleeding endoscopically were randomized to receive either someprazole (n= 19) or Omeprazole (n= 6) 40 mg intravenously q12h for five days. The primary efficacy endpoint was clinical hemostatic effects in 72 h and 120 h after the initial injection, respectively. R SULTS: No significant difference was found between someprazole and Omeprazole groups for the proportion of patients with no clinically significant upper gastrointestinal bleeding within 72 ( P 0105) . The effective rates in both groups after treatment for 120 hours were all 100%. The median hemostatic timewas 41hours in someprazole group compared with 20 hours in Omeprazole group and no significant difference was found between the two groups ( P 0105) . In addition, no severe