替吉奥联合顺铂一线治疗晚期非小细胞肺癌的疗效观察.pdf
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MedJ,2012,Vol44No.5
Qingdao
替吉奥联合顺铂一线治疗晚期
非小细胞肺癌的疗效观察
梁华,宋海平,李然
【摘要】 目的 观察替吉奥联合顺铂一线治疗晚期非小细胞肺癌的有效性和安全性。方法
5.509)。化疗后常见的毒副作用为口腔黏膜炎及神经毒性,而严重的骨髓抑制发生率较低。结论
替吉奥联合顺铂治疗晚期非小细胞肺癌的疗效确切,耐受性良好,给药途径方便,为晚期非小细
胞肺癌的治疗提供了一种新的选择。
【关键词1非小细胞肺癌;化疗;替吉奥
【中图分类号1 R574 【文献标识码】 A
and of
sideeffectscombinationof
Efficacy therapycisplatin
andS-1foradvancednon-small-cellcancer
lun2
LIANG
Hua,SONG
Hal—ping,LI of
Ran.Department
Medical Cancer 266042,China
Oncology(,),QingdaoHospital,Qingdao
Toevaluatethe and of with
treatment
[Abstract]Objectiveefficacytoxicity cisplatinplus
S一1in withadvancednon-small—cellcancer(NSCLC).MethodsAtotalof44cases
patients lung
first—line withS一1(dose basedon surface
accepted chemotherapy adjustmentbody area:40—60mg,
Theremissionrate(CR+PR)
P.O,dl一14)pluscisplatin(25mg/m2,ivdrip,qd,dl一3).Results
was thediseasecontrol
22.7%,and rate(CR+PR+SD)was72.7%.The survivalrate
1-year
was53.5%andmedianPFSwas5.3months(95%CI,5.091-5.509).Therewasmoreoralmu—
cositisand less wasfoundinthis This
neuropathy,andmyelosuppression study.Conclusion
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