斯奇康对过敏性鼻炎患者血清IgE及T细胞亚群的影响-中国病原生物学.DOC

斯奇康对过敏性鼻炎患者血清IgE及T细胞亚群的影响作者简介：吕德华(1968-9)，女,黑龙江哈尔滨人,硕士，副主任医师，研究方向：耳鼻喉科头颈疾病。单位地址：黑龙江省哈尔滨市道里区地段街151号，邮编:150010，E-mail:lidabogx@,Tel吕德华 作者简介：吕德华(1968-9)，女,黑龙江哈尔滨人,硕士，副主任医师，研究方向：耳鼻喉科头颈疾病。 单位地址：黑龙江省哈尔滨市道里区地段街151号，邮编:150010，E-mail:lidabogx@,Tel(哈尔滨市第一医院耳鼻喉科,哈尔滨 150010） [摘 要] 目的：研究斯奇康对过敏性鼻炎患者血清IgE及T细胞亚群的影响。方法：选择我院2012年5月至2015年5月期间确诊的78例过敏性鼻炎患者为研究对象，采用随机数字表法分为观察组(n=40)和对照组(n=38)，观察组患者接受斯奇康联合氯雷他定、孟鲁司特治疗，对照组患者接受氯雷他定、孟鲁司特治疗，比较两组患者的临床症状和体征、血清IgE含量、T细胞亚群、临床疗效等指标。结果：观察组有效率95.00%明显高于对照组76.32% (x2=5.616, P0.05)；治疗后2个月、4个月、6个月时，观察组临床症状、体征评分明显低于对照组(t=6.582, 9.471, 11.016, P0.05)；治疗后6个月时，观察组总免疫球蛋白E (TigE)、特异免疫球蛋白E(sIgE)明显低于对照组，免疫球蛋白G(IgG)含量明显高于对照组(t=12.166, 3.103, 7.004, P0.05)；治疗后6个月，观察组CD4+CD25+Foxp3+阳性细胞、白细胞介素-2 (IL-2)、干扰素(IFN-γ)均明显高于对照组，白细胞介素-4 (IL-4)、白细胞介素-5 (IL-5)明显低于对照组(t=7.253, 8.943, 10.300, 9.615, 7.863, P0.05)。结论：常规药物联合斯奇康注射液肌肉注射治疗有助于缓解患者临床症状和体征，改善免疫功能，降低IgE含量，提高治疗效果。 [关键词]过敏性鼻炎；斯奇康；免疫球蛋白E；调节性T细胞 Effect of BCG-PSN on Serum IgE and T Cell Subsets of Allergic Rhinitis Patients Lv Dehua *，Qu Bin，Gao Yanrong Department of ENT, The first hospital of Harbin,Harbin 150010,China [Abstract] Objective To study the effect of BCG-PSN on serum IgE and T cell subsets of allergic rhinitis patients.Methods:84 patients with allergic rhinitis diagnosed from May 2012 to December 2015 were divided observation group and control group in this study. Observation group patients accepted BCG-PSN combined with loratadine and montelukast treatment, the control group accepted loratadine and montelukast treatment. Then clinical symptoms and signs, serum IgE levels and peripheral blood regulatory T cell, clinical curative effect before and after treatment were compared betweeen two groups. Results: The observation group effective rate 95.00% was significantly higher than the control group 76.32% (x2=5.616, p0.05); 2 months, 4 months, 6 months after treatment, observation group clinical symptoms and signs scores were significantly lower than the control group (t=6.582, 9.