C反应蛋白与白蛋白比值对原发性肝癌患者预后的判断价值-肿瘤防治研究.PDF

598 2016 43 7  Cancer Res Prev Treat,2016,Vol.43,No.7 · · 肿瘤防治研究 年第 卷第 期 doi:10.3971/j.issn.1000-8578.2016.07.011 · · 临床研究 C反应蛋白与白蛋白比值对原发性肝癌患者 预后的判断价值 嫚1 2 李 ，张鹏 Predictive Value of C-reactive Protein/Albumin Ratio on Prognosis of Patients with Primary Hepatocellular Carcinoma LI Man1, ZHANG Peng2 1. Department of Integrated Traditional Chinese and Western Medicine, Hubei Cancer Hospital, Wuhan 430079, China; 2. Department of Pharmacy, Hubei Provincial Hospital of TCM, Wuhan 430061, China Abstract: Objective  To assess the prognostic value of C-reactive protein/albumin (CRP/Alb) ratio on  patients with primary hepatocellular carcinoma (HCC). Methods  A total of 178 cases with HCC were  enrolled. The pre-operative CRP/Alb ratio was calculated. The receiver operating characteristic curve, survival  analysis and multivariate analysis were performed to identify the effect of CRP/Alb ratio on the prognosis  of HCC patients. Results  The best cutoff level for CRP/Alb ratio was 0.46, sensitivity was 70.45%, and  specificity was 73.97%. Compared with the low CRP/Alb group, the high CRP/Alb group showed higher  CRP levels, lower Alb level, higher Child-Pugh grade, larger tumor maximum diameter and larger proportion  of vascular invasion, with statistical significance (P0.001). The Kaplan-Meier curve displayed that lower  survival rate in the high CRP/Alb group than that in low CRP/Alb group (26.8% vs. 56.8%, P0.001). The  Cox multivariate analysis showed that CRP/Alb, Child-Pugh grade and vascular invasion were independent  risk factors for the prognosis. Conclusion  The elevated CRP/Alb ratio at baseline indicates poor prognosis  of patients with HCC, and may be an important independent prognostic factor for the prognosis.