role of cytokines mediating communication between immune cells细胞因子在介导免疫之间通信中作用.pdf

CanonicalPathway

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CanonicalRoleofCytokinesinMediatingCommunicationbetweenImmuneCells

Pathway:

Description:Innateandadaptiveresponsesaretwomainbranchesoftheimmunesystem.Communicationbetweencellsofthesetwobranchesisessentialto

launchingasuccessfulimmuneresponseagainstaforeignantigen.Cytokinesplayacentralroleinmediatingcommunicationbetweenimmunecells.

Immunecellsincludethoseoftheinnatesystemandadaptivesystem.Innatecellsincludeantigenpresentingcells(dendriticcells,macrophagesand

neutrophils),naturalkiller(NK)cells,mastcells,basophilsandeosinophils.AdaptiveimmunecellsincludeBcellsandTcells.Antigenpresentingcells

bridgetheinnateandadaptivebranchesoftheimmunesystem.

Cytokineswhichincludeinterleukins,interferonsandTNFplayaroleinfacilitatingcrosstalkbetweencellsoftheinnateandadaptivesystems.

CytokinessuchasIL-8,IL-1andIL-10producedbymacrophagesleadtotheactivationofneutrophils,mastcellsandbasophils.Dendriticcellsand

macrophagesalsoproduceahostofcytokinesincludingIL-1,IL-15,IL-4,TNFandIFNwhichactivateNKcells,Tcellsandleadtothematurationof

dendriticcells.

BandTcellsareactivatedbycytokinessuchasIL-4,IL-6,IL-10andIL-12.Differenti