基于生物信息学的子宫内膜癌预后模型构建.docx

基于生物信息学的子宫内膜癌预后模型构建

林鹏孙培许淑霞

[关键词]?子宫内膜癌；生物信息学；预后；预测模型

[中图分类号]?R737.3????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.03.011

Construction?of?prognostic?model?for?endometrial?carcinoma?based?on?bioinformatics

LIN?Peng1，?SUN?Pei2，?XU?Shuxia2

1.Department?of?Pathology，?Fujian?Children’s?Hospital?（Fujian?Branch?of?Shanghai?Children’s?Medical?Center），?College?of?Clinical?Medicine?for?Obstetrics??Gynecology?and?Pediatrics，?Fujian?Medical?University，?Fujian?Fuzhou，?350000，?China;?2.Department?of?Pathology，?Fujian?Maternity?and?Child?Health?Hospital，?College?of?Clinical?Medicine?for?Obstetrics??Gynecology?and?Pediatrics，?Fujian?Medical?University，?Fuzhou?350000，?Fujian，?China

[Abstract]?Objective?Differential?genes?related?to?prognosis?of?endometrial?carcinoma?（EC）?were?screened?and?prognostic?models?were?constructed.?Methods?Gene?Expression?data?of?EC?and?normal?control?samples?were?downloaded?from?The?Cancer?Genome?Atlas?（TCGA）?database?andnbsp;Gene?Expression?Omnibus?（GEO）?dataset?GSE63678?to?screen?out?common?differential?genes.?LASSO?regression?analysis?was?used?to?screen?out?the?genes?with?prognostic?significance?and?construct?prognostic?characteristics.?EC?patients?with?complete?information?were?obtained?from?the?TCGA?database?and?randomly?divided?into?the?training?group?and?the?validation?group?in?a?ratio?of?1：1.?In?the?training?group，?survival?curves?were?constructed?based?on?prognostic?characteristics.?Functional?annotation?and?pathway?enrichment?analysis?were?conducted?using?gene?ontology?（GO）?analysis?and?Kyoto?Encyclopedia?of?Genes?and?Genomes?（KEGG）?analysis.?Combined?with?prognostic?features?and?clinical?risk?factors，?a?calibration?curve?and?C-index?were?used?to?evaluate?the?performance?of?the?histogram.?Finally，?use?a?verification?group?for?validation.?Results?A?total?of?4800?and?257?differentially?expressed?genes?were?screened?from?TCGA?and?GEO?databases?respectively，?of?which?73?up-regulated?genes?and?52?down-regulated?genes?were?co-expressed.?6?prog