脑电图结合miR-146a-5p预测阿尔茨海默病患者认知功能.docx

脑电图结合miR-146a-5p预测阿尔茨海默病患者认知功能障碍研究

[关键词]脑电图；微小核糖核酸-146a-5p；阿尔茨海默病；认知功能障碍

[中图分类号]R749.1[文献标识码]A[DOI]10.3969/j.issn.1673-9701.2025.05.007

ElectroencephalographcombinedwithmiR-146a-5ptopredictcognitivedysfunctioninAlzheimer’sdiseasepatients

CHENJiaqi，XIANGHongying，LINGYingchun

DepartmentofSpecialInspection，ShaoxingSeventhPeople’sHospital，Shaoxing312000，Zhejiang，China

[Abstract]ObjectiveToexplorethepredictivevalueofelectroencephalograph（EEG）quantitativeparameterscombinedwithserummicroRNAs（miR）-146a-5pincognitivedysfunctioninpatientswithAlzheimer’sdisease（AD）.MethodsAtotalof96ADpatientsdiagnosedinShaoxingSeventhPeople’sHospitalfromMarch2022toMay2024wereselectedtoassesswhetherthepatientshadcognitiveimpairmentaccordingtotheMontrealcognitivescale（MoCA）score，and40patientswithcognitiveimpairmentweresetasoccurrencegroup（MoCAscorelt;26points）.Atotalof56patientswithnormalcognitivefunctionweresetasnon-developinggroup（MoCAscore≥26points）.Quantitativeelectroencephalography（EEG）parametersandserummiR-146a-5pwerecomparedbetweenthetwogroups.TheriskfactorsofcognitivedysfunctioninADpatientswereanalyzedbyLogisticregression，andreceiveroperatingcharacteristiccurvewasusedtopredictefficacyofEEGquantitativeparametersandserummiR-146a-5poncognitivedysfunctioninADpatients.ResultsTheδfrequencyband，θfrequencyband，andserummiR-146a-5plevelswerelowerinoccurrencegroupthanthoseinnonoccurrencegroup，whileβfrequencybandandαfrequencybandwerehigherinoccurrencegroupthaninthosenonoccurrencegroup（Plt;0.05）.δnbsp;frequencyband，θfrequencyband，miR-146a-5p，age，andyearsofeducationwereriskfactorsforcognitivedysfunctioninADpatients（Plt;0.05）.Theareaunderthecurve（AUC）ofpredictingcognitiveimpairmentinADpatientsusingthecombinationofδfrequencyband，θfrequencyband，βfrequencyband，αfrequencyband，andmiR-146a-5pwas0.908.ThesensitivityofpredictingcognitiveimpairmentinADpatientsusingthecombinationofdeltafrequencyband，δfrequencyband，βfrequencyband，αfrequencyband，andmiR-146a-5pwashigherthanthatofindividualdetection（Plt;0.05）.Conclu