胸腔注射异烟肼治疗结核性胸膜炎疗效的探讨.doc

胸腔注射异烟肼治疗结核性胸膜炎疗效的探讨 　　[摘要] 目的 探讨胸腔注射异烟肼治疗结核性胸膜炎的临床疗效。方法 将84例符合入选标准的结核性胸膜炎患者随机分为对照组（n=42）和观察组（n=42）。对照组给予抗结核药物及胸腔穿刺抽液治疗，观察组在对照组的基础上于给予胸腔注射异烟肼治疗。比较两组患者临床疗效，并随访6个月，比较胸膜肥厚粘连发生情况。结果 观察组的总有效率为92.8%，明显高于对照组76.2%的总有效率，比较差异有统计学意义（P0.05）。随访6个月，观察组2例发生胸膜肥厚粘连，发生率为4.8%，对照组9例发生胸膜肥厚粘连，发生率为21.4%。与对照组相比，观察组胸膜肥厚粘连发生率显著降低（P0.05）。结论 常规治疗基础上给予胸腔注射异烟肼治疗结核性胸膜炎疗效可靠，可以显著提高治疗疗效，并降低胸膜肥厚粘连发生率，临床上值得进一步研究。 　　[关键词] 胸腔注射；异烟肼；结核性胸膜炎；胸膜肥厚粘连 　　[中图分类号] R521 [文献标识码] A [文章编号] 1674-0742（2015）05（a）-0144-02 　　Clinical Observation of Pleural Injection by Isoniazid in the Treatment of Tuberculous Pleurisy 　　YU Can 　　Department of Respiration，Peoples Hospital of Wulong County，Chongqing，408500 China 　　[Abstract] Objective To investigate the clinical effect of pleural injection by isoniazid in the treatment of tuberculous pleurisy.Methods 84 cases of tuberculous pleurisy meeting the inclusion criteria were randomly divided into two groups equally. The control group was given antituberculous drugs and thoracic drainage. Besides that， the observation group was given pleural injection by isoniazid. Then， the curative efficacy and incidence of pachynsis and adherence of pleura after the six-month follow-up were compared between the two groups. Results The observation group had a therapeutic efficiency ratio of 92.8%， which was significantly higher than that of 76.2% in the control group （P0.05）. In the six-month follow-up， there’s two cases of pachynsis and adherence of pleura in the observation group with the incidence of 4.8%， while there’s nine cases of pachynsis and adherence of pleura in the control group with the incidence of 21.4%. In comparison with the control group， the incidence of pachynsis and adherence of pleura in the observation group was statistically lower （P0.05）. Conclusion Treatment of pleural injection by isoniazid in patients with tuberculous pleurisy is effective， which can significantly increase curative efficacy and reduce incidence of pachynsis and adherence of pleura. 　　[Key wo