苯甲酰基脲类杀虫剂伏虫隆的合成.pdf

第 ? 卷第?期 农药 ??????? ?? 年 ?月 ??????????????? ????? ?生产工艺? 苯甲酰基脲类杀虫剂伏虫隆的合成 贾建洪，盛卫坚，高建荣 ?浙江工业大学化学工程与材料学院，杭州 ???? 摘要??伏虫隆是一种新苯甲酰脲类杀虫剂，尤其对有机磷、拟除虫菊酯、氨基甲酸酯三类杀虫剂已产生抗性的 害虫防治效果更佳。采用??二氟硝基苯经氯化、还原合成中间体??二氯??? 二氟苯胺，??二氟苯甲酰胺 与二?三氯甲基?碳酸酯酰化合成另一中间体??二氟苯甲酰异氰酸酯，??二氟苯甲酰异氰酸酯与??二氯??? 二氟苯胺加成得到杀虫剂伏虫隆，总收率为??? 。该工艺具有原料易得、异构体少、反应步骤短等特点。 关键词??伏虫隆，苯甲酰脲，杀虫剂，合成 中图分类号：??????文献标识码：????文章编号：1006-0413(2005)06-263-03 Synthesis of the Benzoylurea Insecticide Teflubenzuron JIA Jian-Hong, SHENG Wei-Jian, GAO Jian-Rong (College of Chemical Engineering and Materials, Zhejiang University of Technology, Hangzhou 310032, China) Abstract: Teflubenzuron is a new benzoylurea insecticide with especially good efficacy in controlling insect pests resistant to organophosphate, synthetic pyrethroid, and carbamate insecticides. The intermediate 3,5-dichloro-2,4- difluoroaniline was synthesized by chlorination and reduction of 2,4-difluoronitrobenzene. An acylation reaction of 2, 6-difluorobenzamide and bis(trichloro- methyl)carbonate produced a second intermediate, 2,6-difluorobenzoly isocyanate. By reacting 3,5-dichloro-2,4-difluoroaniline with 2,6-difluorobenzoly isocyanate, teflubenzuron was syn- thesized with a total yield of 79.3%. This process offers the advantages of ready availability of reactants, low isomer production, and few reaction steps. Key words: teflubenzuron, benzoylurea, insecticide, synthesis 伏虫隆????????? 的化学名称为???? 二氯? ?? 二氟苯甲酰胺与三光气反应制得