紫杉醇化疗在妇科恶性肿瘤中护理体会.doc

精品论文 参考文献 紫杉醇化疗在妇科恶性肿瘤中护理体会 石俊静 李艳丽 路平 杨丹华 (河南省新乡市中心医院 453000) 【中图分类号】R473.71【文献标识码】B【文章编号】1672-5085（2011）47-0306-02 【摘要】目的 探讨紫杉醇在治疗妇科恶性肿瘤治疗中的护理及效果。方法 回顾性分析2009年10月-2011年9月在我院应用紫杉醇为主联合化疗治疗宫颈癌、内膜癌、卵巢癌患者200例的临床资料。结果 188例患者完成全程化疗，12例发生急性过敏反应，重新改用其他化疗方案，其中1例发生过敏性休克。其他常见如：骨髓抑制，消化道反应，脱发，神经毒性等。结论 紫杉醇联合化疗治疗妇科恶性肿瘤化疗过程中，护士要全面掌握化疗药物毒性反应特点，加强药物毒副反应观察，做好各项防范措施，同时做好心理护理，可以预防和减轻毒副反应，保证化疗的顺利进行,并达到预期的治疗效果。 【关键词】紫杉醇 妇科恶性肿瘤 化疗 过敏 护理 Experiences of nursing care in the treatment of 200 patients with gynecology oncology by chemotherapy with Paclitaxel 【Abstract】 Objective: To explore the nursing methods and its effect in the treatment of gynecology oncology by adjuvant chemotherapy with Paclitaxel. Methods: The clinical data of 200 patients were retrospectively analyzed. These patients were admitted from October 2009 to September 2011 and received Paclitaxel chemotherapy for ovarian cancer，cervical cancer and endometrim cancer.Results: 188 patients completed the entire chemotherapy. Acute allergic reaction occurred in 11 patients and they had the other chemotherapy because of the serious allergy，including 1 patient had anaphylactic shock occurred. The other side effect were hematological toxicity，gastroenteric reactions，neurotoxicity，and alopecia. Conc lusion: In the chemotherapy with Paclitaxel for gynecology oncology，nurses shou ld grasp the characteristics of the reaction o f drug toxicity during chemotherapy as much as possible and enhance the observation on drug toxicity and adverse reaction so as to take some preventive measures，while the good psychological care can prevent and reduce side-reactions and ensure the smooth chemotherapy. Thereby the desired the rapeutic effect can be achieved. 【Key words】Paclitaxel Gynecology oncology chemotherapy Allergic reaction Nursing 紫杉醇是一种新型抗微管药物,通过促进微管蛋白聚合抑制解聚,保持微管蛋白稳定,抑制细胞有丝分裂。目前紫杉醇联合顺铂不仅是公认的治疗进展期卵巢癌的一线标准方案，而且用于乳腺癌、胃食管癌、肺癌等的周疗化疗疗效亦得到肯定[1]。在妇科恶性肿瘤中，除卵巢癌外，子宫内膜癌、宫颈癌中应用广泛。但紫杉醇的毒副反应在临床中很常见，甚至导致过敏性休克，给临床护理带来风险。本文回顾分析20