complex interaction of sensory and motor signs and symptoms in chronic crps复杂的相互作用的感觉和运动症状和体征在慢性c反应蛋白.pdf

Complex Interaction of Sensory and Motor Signs and Symptoms in Chronic CRPS 1 1 2 1 1 1 Volker Huge *, Meike Lauchart , Walter Magerl , Antje Beyer , Patrick Moehnle , Wibke Kaufhold , Gustav Schelling1, Shahnaz Christina Azad1 ¨ ¨ 1 Department of Anaesthesiology, Ludwig-Maximilians-Universitat Munchen, Munich, Germany, 2 Center of Biomedicine and Medical Technology (CBTM), Department of ¨ Neurobiology, Medical Faculty Mannheim, Ruprecht-Karls-Universitat Heidelberg, Mannheim, Germany Abstract Spontaneous pain, hyperalgesia as well as sensory abnormalities, autonomic, trophic, and motor disturbances are key features of Complex Regional Pain Syndrome (CRPS). This study was conceived to comprehensively characterize the interaction of these symptoms in 118 patients with chronic upper limb CRPS (duration of disease: 43623 months). Disease- related stress, depression, and the degree of accompanying motor disability were likewise assessed. Stress and depression were measured by Posttraumatic Stress Symptoms Score and Center for Epidemiological Studies Depression Test. Motor disability of the affected hand was determined by Sequential Occupational Dexterity Assessment and Michigan Hand Questionnaire. Sensory changes were assessed by Quantitative Sensory Testing according to the standards of the German Research Network on Neuropathic Pain. Almost two-thirds of all patients exhibited spontaneous pain at rest. Hand force as well as hand motor function were found to be substantially impaired. Results of Quantitative Sensory Testing revealed a distinct p