complete sequencing and pan-genomic analysis of lactobacillus delbrueckii subsp. bulgaricus reveal its genetic basis for industrial yogurt production完成测序和pan-genomic乳酸菌delbrueckii无性系种群的分析。.pdf

Complete Sequencing and Pan-Genomic Analysis of Lactobacillus delbrueckii subsp. bulgaricus Reveal Its Genetic Basis for Industrial Yogurt Production 1,4. 2,5. 1,6. 1 2 2 4 Pei Hao , Huajun Zheng , Yao Yu , Guohui Ding , Wenyi Gu , Shuting Chen , Zhonghao Yu , 2 3 3 2 1 3 Shuangxi Ren , Munehiro Oda , Tomonobu Konno , Shengyue Wang , Xuan Li *, Zai-Si Ji *, Guoping Zhao1,2,5,7* 1 Key Laboratory of Systems Biology/Key Laboratory of Synthetic Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, 2 Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China, 3 Division of Research and Development, Meiji Dairies Corporation, Odawara, Japan, 4 Shanghai Centre for Bioinformation Technology, Shanghai, China, 5 School of Life Science, Fudan University, Shanghai, China, 6 Graduate School of the Chinese Academy of Sciences, Shanghai, China, 7 Department of Microbiology and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China Abstract Lactobacillus delbrueckii subsp. bulgaricus (Lb. bulgaricus) is an important species of Lactic Acid Bacteria (LAB) used for cheese and yogurt fermentation. The genome of Lb. bulgaricus 2038, an industrial strain mainly used for yogurt production, was completely sequenced and compared against the other two ATCC collection strains of the same subspecies. Specific physiological properties of strain 2038, such as lysine biosynthesis, formate production, aspartate-r