curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization姜黄素抑制谷氨酸释放影响泡动员大鼠前额叶的神经末梢.pdf

Int. J. Mol. Sci. 2012, 13, 9097-9109; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Curcumin Inhibits Glutamate Release from Rat Prefrontal Nerve Endings by Affecting Vesicle Mobilization Tzu Yu Lin 1,2, Cheng Wei Lu 1, Shu Kuei Huang 1 and Su Jane Wang 3,4,* 1 Department of Anesthesiology, Far-Eastern Memorial Hospital, Pan-Chiao District, New Taipei City 22060, Taiwan; E-Mails: drlin1971@ (T.Y.L.); drluchengwei@ (C.W.L.); nskh9450n@.tw (S.K.H.) 2 Department of Mechanical Engineering, Yuan Ze University, Taoyuan 320, Taiwan 3 Graduate Institute of Basic Medicine, Jen Catholic University, No.510, Zhongzheng Rd., Xinzhuang District, New Taipei City 24205, Taiwan 4 School of Medicine, Fu Jen Catholic University, No.510, Zhongzheng Rd., Xinzhuang District, New Taipei City 24205, Taiwan * Author to whom correspondence should be addressed; E-Mail: med0003@.tw; Tel.: +886-2 Fax: +886-2 Received: 20 June 2012; in revised form: 11 July 2012 / Accepted: 16 July 2012 / Published: 20 July 2012 Abstract: Curcumin, one of the major constituents of Curcuma longa, has been shown to inhibit depolarization-evoked glutamate release from rat prefrontocortical nerve terminals by reducing voltage-dependent Ca2+ entry. This study showed that curcumin inhibited ionomycin-induced glutamate release and KCl-evoked FM1-43 release, suggesting that some ste