微反应器中的不对称光化学反应3.PDF

第 16 卷 第 3 期 化　学　进　展 Vol. 16 No. 3 2004 年 5 月 PROGRESS IN CHEMISTRY 　May , 2004 微反应器中的不对称光化学反应3 马　磊　陈　彬　吴骊珠3 3 　彭明丽　张丽萍　佟振合3 3 ( 中国科学院理化技术研究所 　北京 100101) 摘 　要 　化学反应的手性诱导一直备受化学家的关注 ,虽然不对称热化学合成和手性技术已经取得了 巨大的进展 ,但不对称光化学反应的研究远远没有取得相应的成功。激发态寿命短、活化能低是导致其对映 选择性低的主要原因。最新的研究表明 ,采用含手性空间或经手性修饰的微环境可以使光化学反应的立体 选择性大大提高。本文针对这一热点问题 ,综述在微反应器中进行不对称光化学反应的研究进展。 关键词 　微反应器 　不对称光化学反应 　不对称诱导 ( ) 中图分类号: O62113 ; O64411 　文献标识码 : A 　文章编号 : 2004 0320386207 Asymmetric Photochemical Reactions Conducted within Microreactors 3 3 3 3 Ma Lei 　Chen Bin 　Wu Lizhu 　Peng Mingli 　Zhang Liping 　Tung Chenho ( Technical Institute of Physics and Chemistry , Chinese Academy of Sciences , Beijing 100101 , China) Abstract 　Enantioselectivity of chemical reactions continues to be one of the main concerns of chemists. While many elegant and efficient chiral induction strategies have been developed for a variety of thermal reactions , there are considerably fewer examples of asymmetric induction in photochemical transformations. Short excited state lifetime and low activation energy for reactions in the excited states leave little room for manipulating the diastereomeric transition state when the photochemical reactions occur in solution. The latest progress of asymmetric photochemical reactions revealed that the enantioselectivity in photochemical reactions could be achieved when the reactions take place in chiral environ2 ments , which will be rev