cubn as a novel locus for end-stage renal disease insights from renal transplantationcubn作为终末期肾病的见解新颖的轨迹从肾移植.pdf

CUBN as a Novel Locus for End-Stage Renal Disease: Insights from Renal Transplantation 1 2 1 1 3 Anna Reznichenko *, Harold Snieder , Jacob van den Born , Martin H. de Borst , Jeffrey Damman , 4 4 5 4 Marcory C. R. F. van Dijk , Harry van Goor , Bouke G. Hepkema , Jan-Luuk Hillebrands , 3 3 1 1 1 Henri G. D. Leuvenink , Jan Niesing , Stephan J. L. Bakker , Marc Seelen , Gerjan Navis , on behalf of the REGaTTA (REnal GeneTics TrAnsplantation) Groningen group 1 Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 2 Unit of Genetic Epidemiology Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 3 Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 4 Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 5 Department of Transplant Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Abstract Chronic kidney disease (CKD) is a complex disorder. As genome-wide association studies identified cubilin gene CUBN as a locus for albuminuria, and urinary protein loss is a risk factor for progressive CKD, we tested the hypothesis that common genetic variants in CUBN are associated with end-stage renal disease (ESRD) and proteinuria. First,