肾脏捐献者终末期肾病患病风险更高.pdf

Research Original Investigation Risk of End-Stage Renal Disease Following Live Kidney Donation Abimereki D. Muzaale, MD, MPH; Allan B. Massie, PhD; Mei-Cheng Wang, PhD; Robert A. Montgomery, MD, DPhil; Maureen A. McBride, PhD; Jennifer L. Wainright, PhD; Dorry L. Segev, MD, PhD Editorial page 577 IMPORTANCE Risk of end-stage renal disease (ESRD) in kidney donors has been compared Supplemental content at with risk faced by the general population, but the general population represents an unscreened, high-risk comparator. A comparison to similarly screened healthy nondonors would more properly estimate the sequelae of kidney donation. OBJECTIVES To compare the risk of ESRD in kidney donors with that of a healthy cohort of nondonors who are at equally low risk of renal disease and free of contraindications to live donation and to stratify these comparisons by patient demographics. DESIGN, SETTINGS, AND PARTICIPANTS A cohort of 96 217 kidney donors in the United States between April 1994 and November 2011 and a cohort of 20 024 participants of the Third National Health and Nutrition Examination Survey (NHANES III) were linked to Centers for Medicare Medicaid Services data to ascertain development of ESRD, which was defined as the initiation of maintenance di