羟基磷灰石基活性生物陶瓷的制备方法研究.doc

摘要 羟基磷灰石( HA ) 是一种典型的生物材料,具有优良的生物相容性和生物活性, 能与骨形成紧密的结合。大量的生物相容性实验证明羟基磷灰石无毒、无刺激、不致过敏反应、不致突变、不致溶血, 不破坏生物组织, 并能与骨形成牢固的化学结合, 是一种很有应用前景的人工骨和人工口腔材料; HA 的合成有很多方法, 大体分为固相法合成和液相法合成,本文采用化学沉淀法和自燃烧法制备羟基磷灰石粉体，化学沉淀法主要以Ca（NO3）2H3PO4溶液以及氨水为原料，制备羟基磷灰石粉体。自燃烧法采用天然兽骨为原料，高温煅烧制备粉体。实验中利用XRD、激光粒度分析仪分析手段对粉体制备工艺参数进行研究。 在粉体制备过程中，化学沉淀法采用分散剂减少粉体的团聚。对硝酸钙溶液的浓度以及不同分散剂的分散效果进行了研究。结果表明Ca（NO3）2mol/L并且使用无水乙醇作分散剂时所得的粉体纯度高，分散性好。 关键词：羟基磷灰石；化学沉淀法；自燃烧法 Abstract Hydroxyapatite (HA) is a typical biological materials, with excellent biocompatibility and biological activity, which can be closely integrated with bone formation. A large number of Biocompatibility experiments show HA is non-toxic, not excitant, not allergic reaction, not mutation, without hemolysis, and it does not destroy the biological tissue, and it can also be strong chemical combination with bone ,so it is a good application prospect of artificial bone and artificially oral material .HA can prepare in many ways which divided into solid-phase synthesis and liquid phase synthesis method.In this paper, we use the chemical precipitation method and the combustion method to prepare the hydroxyapatite powders. In chemical precipitation,HA can be prepared by Ca (NO3) 2 solution, H3PO4 solution and ammonia. In the combustion method, HA can be prepared by animal bones at high temperature.In the experiment we analyzed the Powder preparation process parameters by XRD and . Laser particle size analyzer. In powder preparation process, the chemical precipitation method uses dispersant to reduce powder agglomeration. And we investigate Ca (NO3) 2 solution concentration and dispersion of different dispersants . The results showed that powders will be high purity and good dispersion when Ca (NO3) 2 concentration was 0.2mol / L and PVA was used as dispersant Key words: Hydroxyapatite (HA); chemical precipitation method; combustion method 目 录 摘要 I Abstract II 第1章 绪论 1 1.1引言 1 1.2生物活性陶瓷 1 1.2.1生物活性陶瓷的种类及特点 1 1.2.2生物陶瓷的现状和发展趋势 2 1.2.3羟基磷灰石的研究现