the cost of relapse and the predictors of relapse in the treatment of schizophrenia成本的复发和治疗精神分裂症复发的预测因素.pdf

Ascher-Svanum et al. BMC Psychiatry 2010, 10:2 /1471-244X/10/2 RESEARCH ARTICLE Open Access The cost of relapse and the predictors of relapse in the treatment of schizophrenia 1* 2 2 3 4,5 2 Haya Ascher-Svanum , Baojin Zhu , Douglas E Faries , David Salkever , Eric P Slade , Xiaomei Peng , Robert R Conley6 Abstract Background: To assess the direct cost of relapse and the predictors of relapse during the treatment of patients with schizophrenia in the United States. Methods: Data were drawn from a prospective, observational, noninterventional study of schizophrenia in the United States (US-SCAP) conducted between 7/1997 and 9/2003. Patients with and without relapse in the prior 6 months were compared on total direct mental health costs and cost components in the following year using propensity score matching method. Baseline predictors of subsequent relapse were also assessed. Results: Of 1,557 participants with eligible data, 310 (20%) relapsed during the 6 months prior to the 1-year study period. Costs for patients with prior relapse were about 3 times the costs for patients without prior relapse. Relapse was associated with higher costs for inpatient services as well as for outpatient services and medication. Patients with prior relapse were younger and had onset of illness at earlier ages, poorer medication adherence, more severe symptoms, a higher prevalence of substance use disorder, and worse functional status. Inpatient costs for patients with a relapse during both the prior 6 months and the follow-up year were 5 times the costs for patients with relapse during the follow-up year only. Prior relapse was a robust predictor of subsequent relapse, above and beyond information