the glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia神经胶质生长因子缺乏和突触不稳定假说的精神分裂症.pdf

BMC Psychiatry BioMed Central BMC Psychiatry x 2002, 2 Hypothesis The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia 1 2 3 Hans W Moises* , Tomas Zoega and Irving I Gottesman Address: 1Molecular Genetics Laboratory, Department of Psychiatry, Kiel University Hospital, Niemannsweg 147, 24105 Kiel, Germany, 2Department of Psychiatry, National University of Iceland, Reykjavik, Iceland and 3Departments of Psychiatry and Psychology, University of Minnesota, Minneapolis, USA E-mail: Hans W Moises* - moises@psychiatry.uni-kiel.de; Tomas Zoega - tomasz@landspitali.is; Irving I Gottesman - gotte003@ *Corresponding author Published: 3 July 2002 Received: 9 May 2002 Accepted: 3 July 2002 BMC Psychiatry 2002, 2:8 This article is available from: /1471-244X/2/8 © 2002 Moises et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the articles original URL. Abstract Background: A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors. Presentation of the hypothesis: Based on a co-localization of loci approach and a large amount of circumstantial evidence, we here propose that a functional deficiency of glial growth factors and of growth factors produced by glial cells