the core and accessory genomes of burkholderia pseudomallei implications for human melioidosis的核心和辅助基因组伯克对人类类鼻疽举办的影响.pdf

The Core and Accessory Genomes of Burkholderia pseudomallei: Implications for Human Melioidosis 1. 2. 2 2 3 Siew Hoon Sim , Yiting Yu , Chi Ho Lin , R. Krishna M. Karuturi , Vanaporn Wuthiekanun , Apichai 4 2 1 1 1 Tuanyok , Hui Hoon Chua , Catherine Ong , Sivalingam Suppiah Paramalingam , Gladys Tan , Lynn 1 1 1 4 5 3,6 2,7 Tang , Gary Lau , Eng Eong Ooi , Donald Woods , Edward Feil , Sharon J. Peacock *, Patrick Tan * 1 Defense Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Republic of Singapore, 2 Genome Institute of Singapore, Singapore, Republic of Singapore, 3 Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 4 Faculty of Medicine, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada, 5 Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom, 6 Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, United Kingdom, 7 Duke-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore Abstract Natural isolates of Burkholderia pseudomallei (Bp), the causative agent of melioidosis, can exhibit significant ecological flexibility that is likely reflective of a dynamic genome. Using whole-genome Bp microarrays, we exam