the coronis trial. international study of caesarean section surgical techniques a randomised fractional, factorial trialcoronis试验。.pdf

BMC Pregnancy and Childbirth BioMed Central Study protocol Open Access The CORONIS Trial. International study of caesarean section surgical techniques: a randomised fractional, factorial trial The CORONIS Trial Collaborative Group Address: National Perinatal Epidemiology Unit, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK Email: The CORONIS Trial Collaborative Group - peter.brocklehurst@npeu.ox.ac.uk Published: 22 October 2007 Received: 14 August 2007 Accepted: 22 October 2007 BMC Pregnancy and Childbirth 2007, 7:24 doi:10.1186/1471-2393-7-24 This article is available from: /1471-2393/7/24 © 2007 The CORONIS Trial Collaborative Group; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Caesarean section is one of the most commonly performed operations on women throughout the world. Rates have increased in recent years – about 20–25% in many developed countries. Rates in other parts of the world vary widely. A variety of surgical techniques for all elements of the caesarean section operation are in use. Many have not yet been rigorously evaluated in randomised controlled trials, and it is not known whether any are associated with better outcomes for women and babies. Because huge numbers of women undergo caesarean section, even small differences in post-operative morbidity rates between techniques could translate into improved health for substantial numbers