biodegradable polymers in bone tissue engineering生物可降解聚合物在骨组织工程.pdf

Materials 2009, 2, 833-856; doi:10.3390/ma2030833 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Biodegradable Polymers in Bone Tissue Engineering Robert J. Kroeze 1,2,3, Marco N. Helder 1,3, Leon E. Govaert 4 and Theo H. Smit 1,3,* 1 Department of Orthopaedic Surgery, VU University Medical Center, Amsterdam, The Netherlands; E-Mail: r.kroeze@vumc.nl (R.K.); m.helder@vumc.nl (M.H.) 2 Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Universiteit van Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands 3 MOVE/Skeletal Tissue Engineering Group Amsterdam (STEGA), Amsterdam, The Netherlands 4 Faculty of Mechanical Engineering, Polymer Technology, Eindhoven University of Technology, Eindhoven, The Netherlands; E-Mail: aert@tue.nl (L.G.) * Author to whom correspondence should be addressed; E-Mail: th.smit@vumc.nl; Tel. +31-20-4442355; Fax +31-20-4442357 Received: 2 July 2009; in revised form: 21 July 2009 / Accepted: 24 July 2009 / Published: 24 July 2009 Abstract: The use of degradable polymers in medicine largely started around the mid 20th century with their initial use as in vivo resorbing sutures. Thorough knowledge on this topic as been gained since then and the potential applications for these polymers were, and still are, rapidly expanding. After improving the properties of lactic acid-based polymers, these were no longer studied only from a scientific point of view, but also for their use in bone surgery in the 1990s. Unfort