biphasic calcium phosphate ceramics for bone regeneration and tissue engineering applications双相磷酸钙陶瓷的骨再生和组织工程的应用.pdf

Materials 2010, 3, 815-826; doi:10.3390/ma3020815 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Biphasic Calcium Phosphate Ceramics for Bone Regeneration and Tissue Engineering Applications Sonja Ellen Lobo 1,2 and Treena Livingston Arinzeh 2,* 1 Department of Morphology, Federal University of São Paulo, Rua Botucatu, 740, CEP 04023-900, São Paulo, SP, Brazil; E-Mail: sonjael@.br 2 Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights; 614 Fenster Hall, Newark, NJ 07102-1982, USA * Author to whom correspondence should be addressed; E-Mail: arinzeh@; Tel.: +1-973-596-5269. Received: 1 December 2009; in revised form: 17 January 2010 / Accepted: 27 January 2010 / Published: 29 January 2010 Abstract: Biphasic calcium phosphates (BCP) have been sought after as biomaterials for the reconstruction of bone defects in maxillofacial, dental and orthopaedic applications. They have demonstrated proven biocompatibility, osteoconductivity, safety and predictability in in vitro, in vivo and clinical models. More recently, in vitro and in vivo studies have shown that BCP can be osteoinductive. In the field of tissue engineering, they represent promising scaffolds capable of carrying and modulating the behavior of stem cells. This review article will highlight the latest advancements in the use of BCP and the characteristics that create a unique microenvironment that favors bone regeneration. Keywords: