targeting protein-protein interactions for parasite control针对寄生虫控制蛋白质-蛋白质之间的关系.pdf

Targeting Protein-Protein Interactions for Parasite Control 1 2 1 1 1 Christina M. Taylor , Kerstin Fischer , Sahar Abubucker , Zhengyuan Wang , John Martin , Daojun 2 3 ¨ 3 2 2 1 Jiang , Marc Magliano , Marie-Noelle Rosso , Ben-Wen Li , Peter U. Fischer , Makedonka Mitreva * 1 Department of Genetics, The Genome Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, 3 INRA 1301, CNRS 6243, UNSA, Interactions ´ ´ ´ Biotiques et Sante Vegetale, Sophia-Antipolis, France Abstract Finding new drug targets for pathogenic infections would be of great utility for humanity, as there is a large need to develop new drugs to fight infections due to the developing resistance and side effects of current treatments. Current drug targets for pathogen infections involve only a single protein. However, proteins rarely act in isolation, and the majority of biological processes occur via interactions with other proteins, so protein-protein interactions (PPIs) offer a realm of unexplored potential drug targets and are thought to be the next-generation of drug targets. Parasitic worms were chosen for this study because they have deleterious effects on human health, livestock, and plants, costing society billions of dollars annually and many sequenced genomes are available. In this study, we present a computational approach that utilizes whole genomes of 6 parasitic and 1 free-l