血管内皮生长因子在多囊卵巢综合征患者卵巢组织中表达.doc

血管内皮生长因子在多囊卵巢综合征患者卵巢组织中表达[摘要] 目的:探讨血管内皮生长因子(VEGF)在多囊卵巢综合征(PCOS)的发生及发展中的作用。方法:选择2007年10月~2009年2月我院收治的40例PCOS患者及32例单侧卵巢囊肿患者,应用免疫组化SP法检测卵巢组织中VEGF的表达。结果:PCOS组和对照组卵巢颗粒细胞和间质细胞VEGF表达强度差异有统计学意义(P [2]Solomon CG. The epidemiology of polycystic ovary syndrome: prevalence and associated disease risks [J]. Endocrinol Metab Clin North Am,1999, 28(2):247-264. [3]Pan HA, Wu MH, Cheng YC, et al. Quantification of Doppler signal in polycystic ovary syndrome using three-dimensional power Doppler ultrasonography: a possible new marker for diagnosis [J]. Hum Reprod,2002,17(9):201-206. [4]陆湘,汪玉宝.胰岛素抵抗、瘦素与多囊卵巢综合征[J].中国全科医学,2004,7(2):127. [5]Geisthovel F. A comment on the European society of human reproduction and embryology/american society for reproductive medicine consensus of the polycystic ovarian syndrome [J]. Reprod Biomed Online,2003,7(6):602-605. [6]冯淑英.PCOS胰岛素抵抗发生机制与无排卵[J].实用妇产科杂志,2005,21(9):517. [7]Legro RS, Strauss JF. Molecular progress in infertility: polycystic ovary syndrome [J]. Fertil Steril,2002,78(3):569-576. [8]Artini PG, Monti M, Matteucci C, et al. Vascular endothelial growth factor and basic fibroblast growth factor in polycystic ovary syndrome during controlled ovarian hyperstimulation [J]. Gynecol Endocrinol,2006,22(8):465-470. [9]Fulghesu AM, Ciampeli M, Belosi C, et al. A new ultrasound criterion for the diagnosis of polycytic ovary syndrome: the ovarian stroma/total area ratio [J]. Fertil Steril,2001,77(2):326-331. [10]Resende AV, Mendes MC, deMoura MD, et al. Doppler study of the uterine arteries and ovarian stroma in patients with polycystic ovary syndrome [J]. Gynecol Obestet Invest,2001,52(3):153-157. [11]Amin AF, Abdel-Aal DE, Darwish AM, et al. Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor, and insulin-like growth factor-1 in women with polycystic ovary syndrome [J]. Fertil Steril,2003,79(4):938-941. [12]Grawal A,