药物性肝病109例临床分析.pdf

40 C in J Clin iH epato,l February 2007, V ol23, N o1 109 傅婷婷, 王 峰 (吉林大学第一医院, 吉林长春 130021) ! 109 , 514% ( 56/ 109) , 486% ( 53/109), ( 569% ) ( 431% ) , 1~ 8 , !; ; ; !R575 !B ! 1001- 5256(2007) 01- 0040- 02 C lin ical analy sis of 109 cases w ith dru g- induced liver d isease. FU T ing - ting, WAN G Feng. ( The F irs tH osp ita l of J ilin Un iv ersity, Chang chun 130021, Ch ina) A bstrac t: To investigate t e clin ical c aracteristics of patientsw it drug- induced liver d isease and drugs resulting in t e liver injuries. T em ed ication taking istory, clinicalm anifestation, liver function test and prognosisw ere analyzed com pre ensively w it retrospective review. M any drugs cou ld induce liver d isease. T e trad itional C inesem edicine accounted for 514% ( 56/ 109). Among t em, t e drugs treating for sk in disease and t e bone joint system d isease w ere t e predom i nant. T e w estern m edicine accounted for 486% (53/ 109), am ong w ic t em ost c ief drugsw ere anti- inflamm atory, antipyretic, antituberculotic and antit yroid drugs. T e num ber of fem ale patien ts ( 569% ) w as m ore t an t e m ale pa tients ( 431% ). T e latent period varied 1- 8 w eeks. T e m ost frequent clinical type w as t e epatocellu lar dam age type. T e mi portance of t e prevention, d iagnos is and t erapy of t e d isease s ou ld be em p asized, especially t e disease w ic was induced by trad itional C inesem edicine. K ey w ord s: drug- induced liver d isease; drugs; epatitis; compre ensive analysis ; [ 1] , [ 2] , HBsAg, , 1000 [ 3, 4] , , ; ∋ ,