strontium ions substitution in brushite crystals the role of strontium chloride锶离子替换在透钙磷石晶体氯化锶的角色.pdf

J. Funct. Biomater. 2011, 2, 31-38; doi:10.3390/jfb2020031 OPEN ACCESS Journal of Functional Biomaterials ISSN 2079-4983 /journal/jfb/ Article Strontium Ions Substitution in Brushite Crystals: The Role of Strontium Chloride Mohammad H. Alkhraisat *, Carmen Rueda and Enrique López Cabarcos Departamento de Química Física II, Facultad de Farmacia, UCM, 28040 Madrid, Spain; E-Mails: crueda@farm.ucm.es (C.R.); cabarcos@farm.ucm.es (E.L.C.) * Author to whom correspondence should be addressed; E-Mail: mkhresat@farm.ucm.es. Received: 8 April 2011; in revised form: 16 May 2011 / Accepted: 30 May 2011 / Published: 31 May 2011 Abstract: The incorporation of strontium chloride to brushite cement was successful to introduce strontium ions within the lattice of brushite crystals. The effect of strontium ions on brushite cement properties was concentration dependent; such that, the addition of 5% and 10% (w/w) SrCl2 significantly increased the cement FST and the addition of 10% SrCl2 decreased the cement tensile strength. Further, cement weight loss was shown to be increased by cement modification with SrCl . The combination of ionic substitution and 2 the degradability of brushite cements would constitute a system for the lo