the adverse neuro-developmental effects of postnatal steroids in the preterm infant a systematic review of rcts产后类固醇的不良神经发育影响的早产婴儿相关的系统评价.pdf

BMC Pediatrics (2001) 1:1 /1471-2431/1/1 BMC Pediatrics (2001) 1:1 Meta-analysis The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs Keith J Barrington* Address: Royal Victoria Hospital, 687 Pine Ave W. Room C7.68, Montreal, Quebec, H3A 1A1 Canada E-mail: Keith J Barrington* - kbarri@po-box.mcgill.ca *Corresponding author Published: 27 February 2001 Received: 20 November 2000 Accepted: 27 February 2001 BMC Pediatrics 2001, :1 This article is available from: /1471-2431/1/1 (c) 2001 Barrington, licensee BioMed Central Ltd. Abstract Background: Recent reports have raised concerns that postnatal steroids may cause neuro- developmental impairment in preterm infants. This systematic review was performed with the objective of determining whether glucocorticoid therapy, to prevent or treat bronchopulmonary dysplasia, impairs neuro-developmental outcomes in preterm infants. Method: A systematic review of the literature was performed. Medline was searched and articles retrieved using predefined criteria. Data from randomized controlled trials with adequate neuro- developmental follow up (to at least one year) were entered into a meta-analysis to determine the effects of postnatal treatment of preterm infants with glucocorticoids. Cerebral palsy rates, and neuro-developmental impairment (developmental score more than 2SD below the mean, or cerebral palsy or blindness) were analyzed. The studies were divided into 2 groups according to the extent of contamination of the results by treatment of