bacterial sepsis in brazilian children a trend analysis from 1992 to 2006细菌性败血症在巴西的孩子从1992年到2006年这一趋势分析.pdf

Bacterial Sepsis in Brazilian Children: A Trend Analysis from 1992 to 2006 1 2 3 Cristina Malzoni Ferreira Mangia , Niranjan Kissoon *, Otavio Augusto Branchini , Maria Cristina 1 1 4 Andrade , Benjamin Israel Kopelman , Joe Carcillo ˜ ˜ 1 Department of Pediatrics, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, Brazil, 2 Division of Critical Care, Department of Pediatrics, ˜ University of British Columbia, Child and Family Research Institute, Vancouver, Canada, 3 Hospital Emilio Ribas, Sao Paulo, Brazil, 4 Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Background: The objective of this study was to determine the epidemiology of hospitalized pediatric sepsis in Brazil (1992– 2006) and to compare mortality caused by sepsis to that caused by other major childhood diseases. Methods and Findings: We performed a retrospective descriptive study of hospital admissions using a government database of all hospital affiliated with the Brazilian health system. We studied all hospitalizations in children from 28 days through 19 years with diagnosis of bacterial sepsis defined by the criteria of the International Classification of Diseases (ICD), (Appendix S1). Based on the data studied from 1992 through 2006, the pediatric hospital mortality rate was 1.23% and there were 556,073 pediatric adm