子宫颈癌筛查方法比较研究.doc

子宫颈癌筛查方法比较研究 　　[摘要]目的 探讨传统巴氏细胞学筛查、液基细胞学筛查以及人乳头瘤病毒（HPV）DNA检测在子宫颈癌患者筛查中的应用效果。方法 选取2013年1月～2016年2月在我院接受子宫颈癌筛查患者800例作为研究对象，患者均给予传统巴氏细胞学筛查、液基细胞学筛查、HPV DNA筛查以及阴道镜检查，以患者病理组织学筛查结果作为最终标准，对比不同检查方法的检查结果。结果 800例患者经巴氏涂片法筛查结果显示阳性者102例（12.8%）、液基细胞学筛查结果显示阳性者112例（14.0%）、HPV DNA筛查方法显示阳性患者205例（25.6%）、病理学筛查结果显示为103例（12.9%），且液基细胞学筛查结果与病理学筛查结果一致性最高，与其他两种筛查方法比较，差异有统计学意义（P0.05）。结论 液基细胞学可以作为子宫颈癌以及癌前病变的首选筛查方法，其与患者病理学检查结果一致性最高，值得临床推广。 　　[关键词]子宫颈癌；巴氏细胞学；液基细胞学；人乳头瘤病毒 　　[中图分类号] R711.74 [文献标识码] A [文章编号] 1674-4721（2016）10（c）-0140-03 　　[Abstract]Objective To explore effect of the traditional pap smear cytology，liquid based cytology and human papillomavirus （HPV） application of DNA detection in the screening of patients with cervical cancer.Methods 800 patients with cervical cancer in our hospital from January 2013 to February 2016 were selected as the research object，the patients were given conventional pap smear cytology，liquid based cytology，human papillomavirus DNA screening and colposcopy in screening patients with pathological results as the final standard，the different inspection methods of the inspection results were compared.Results 800 cases of patients with pap smear screening showed that 102 cases were positive （12.8%），the results of liquid based cytology showed 112 cases were positive （14.0%） the screening method，HPV DNA positive patients showed 205 cases （25.6%），pathology screening results showed 103 cases （12.9%）.The results of screening and screening results of liquid based cytology and pathology The highest consistency，which had significant difference with other two kinds of screening methods for comparison （P0.05）.Conclusion Liquid based cytology can be used as the preferred method of screening for cervical cancer and precancerous lesions，the patients with pathological results of the highest consistency，which is worthy of clinical application. 　　[Key words]Cervical cancer；Pap smear cytology；Liquid based cytology；Human papilloma virus 　　子宫颈癌是当前临床极为常见的一种妇科恶性肿瘤疾病，其在全球范围内的病发率高居女