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bacterial community assembly and turnover within the intestines of developing zebrafish肠道内的细菌群落组装和营业额发展中斑马鱼.pdf

发布:2017-08-29约6.99万字共7页下载文档
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Bacterial Community Assembly and Turnover within the Intestines of Developing Zebrafish 1 2 1 Qingyun Yan , Christopher J. van der Gast , Yuhe Yu * 1 Key Laboratory of Biodiversity and Conservation of Aquatic Organisms, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, 2 NERC Centre for Ecology and Hydrology, Wallingford, United Kingdom Abstract Background: The majority of animal associated microorganisms are present in digestive tract communities. These intestinal communities arise from selective pressures of the gut habitats as well as host’s genotype are regarded as an extra ‘organ’ regulate functions that have not evolved wholly on the host. They are functionally essential in providing nourishment, regulating epithelial development, and influencing immunity in the vertebrate host. As vertebrates are born free of microorganisms, what is poorly understood is how intestinal bacterial communities assemble and develop in conjunction with the development of the host. Methodology/Principal Findings: Set within an ecological framework, we investigated the bacterial community assembly and turnover within the intestinal habitats of developing zebrafish (from larvae to adult animals). Spatial and temporal species-richness relationships and Mantel and partial Mantel tests revealed that turnover was low and that richness and composition was best predicted by time and not intestinal volume (habitat size) or changes in food diet. We also observed that bacterial communities within the zebrafish intestines were deterministically assembled (reflected by the observed low turnover) switching to stochastic assembly in the later stages of zebrafish development. Conclusions/Significance: This st
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