strain-specific virulence phenotypes of streptococcus pneumoniae assessed using the chinchilla laniger model of otitis media钦奇利亚毒株特异性毒性肺炎链球菌的表型评估使用laniger中耳炎的典范.pdf

Strain-Specific Virulence Phenotypes of Streptococcus pneumoniae Assessed Using the Chinchilla laniger Model of Otitis Media 1,2.¤ 2. 2 2,3,4 2 Michael L. Forbes , Edward Horsey , N. Luisa Hiller , Farrel J. Buchinsky , Jay D. Hayes , James M. 2 2,5 2 2 2 6 Compliment , Todd Hillman , Suzanne Ezzo , Kai Shen , Randy Keefe , Karen Barbadora , J. Christopher Post2,3,4, Fen Ze Hu2,4, Garth D. Ehrlich2,4* 1 Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America, 2 Center for Genomic Sciences, Allegheny General Hospital- Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, 3 Department of Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America, 4 Department of Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America, 5 Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America, 6 Department of Pediatrics, Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Background: Streptococcus pneumoniae [Sp] infection is associated with local and systemic disease. Our current understanding of the differential contributions of genetic strain variation, serotype, and host response to disease phenotype is incomplete. Using the chinchilla model of otitis media [OM] we investigated the disease phenotype generated by the laboratory strain TIGR4 and each of thirteen clinical strains (B