丹参酮IIA磺酸钠注射对急性脑梗死患者血流变学的影响分析.doc

丹参酮IIA磺酸钠注射对急性脑梗死患者血流变学的影响分析 　　【摘要】 目的 观察丹参酮IIA磺酸钠注射液对急性脑梗死患者血流变学的影响并观察临床疗效。方法 将急性脑梗死患者118例随机分为治疗组和对照组，对照组57例采用常规治疗,治疗组61例在对照组基础上加用丹参酮IIA磺酸钠60 mg静脉滴注，1次/d，14 d为一个疗程。所有病例均于治疗前后检测血液流变学指标，疗效按临床神经功能缺损程度评分(NDS)标准进行量化评定。结果 治疗组及对照组治疗前血液流变学各项指标均表现为不同程度的异常，治疗组治疗前后血液流变学各项指标明显改善(P0.05)，两组治疗后相比较差异有统计学意义(P0.05)。在临床疗效方面，治疗组总显效率为90.16％，对照组总显效率为80.7％，两组比较均差异有统计学意义(P0.05)。结论 丹参酮IIA磺酸钠注射液可明显改善急性脑梗死患者血液流变学指标，其临床疗效明显。? 　　【关键词】 　　脑梗死；血流变学；丹参酮IIA 　　 　　Effect of Sodium Tanshinone lIA on hemorheology in patients with acute cerebral infarction 　　 　　【Abstract】 Objective 　　To observe the effects of Sodium Tanshinone lIA on hemorheology in patients with acute cerebral infarction.Methods One hundred and eighteen patients with acute cerebral infarction were randomly divided into a treatment group and a control group.The control group(57 subjects)were treated with conventional therapy,and the treatment group(61 subjects)were treated with Sodium Tanshinone lIA(60 mg ivdrip qd)combined with conventional therapy.The total period of treatment was 14 days.Neurological functional deficit score(NDS)was assessed and hemorheological indexes were determined before and after the treatment. Results There was abnormal hemorrheological properties in all patients with acute cerebral infarction before treatment.The changes of indexes of hemorheology were obvious in the treatment group before and after treatment(P0.05).There was significant differences between two groups after treatment(P0.05).Clinical effect assessment results:in treatment group,total effective rate was 90.16％, in control group,total effective rate was 80.7％,there was significant differences between two groups after treatment(P0.05).Conclusion Hemorheological index can be improved significantly in patients with acute cerebral infarction after being treated with Sodium tanshioneⅡA,which may contribute to the recovery of nerve function.? 　　【Key words】 　　cerebral Infarction； Hemorheology；Sodium Tanshinone IIA 　　? 　　作者单位：253600山东省乐陵市人民医