丙泊酚雷米芬太尼靶控输注在心脏手术中的应用.pdf

．临床研究． 丙泊酚一雷米芬太尼靶控输注在心脏手术中的应用 林霖 李立环岳云 于布为 【摘要】 目的观察丙泊酚一雷米芬太尼靶控输注(TCI)在心脏瓣膜置换术和冠状动脉旁路移 植术中使用的安全性、有效性以及对术后恢复的影响。方法 择期心脏手术患者150例，以丙泊酚 TCI、雷米芬太尼3～5pg／kg诱导，丙泊酚一雷米芬太尼2～8ng／mlTCI维持，维持脑电双频指数 (BIS)于50士10。观察术中血流动力学指标和术后恢复情况。结果所有患者术巾血流动力学平稳， ng／rrd]复合丙泊酚[血浆浓度 术后恢复良好，无术中知晓。结论雷米芬太尼[效应部位浓度(Ce)2～8 (Cp)1～2vg／nd3用于心脏手术的麻醉安全有效．血流动力学平稳，有利于术后早期气管拔管。 【关键词】 丙泊酚；靶控输注；血流动力学 infusionof andremifentanilin cardiac LlN undergoingsurgery Target-controlledpropofol patients Li，l。L，Li．huan，YUEYun，et Instituteand砌 a1．DepartmentofAnesthesiology，Cardiovascular wai MedicalSciencesand UnionMedical Hospital。ChineseAcademyof Peking College，Beijing 100037，China a intravenousanesthetic Toassessthe and of total [Abstract]0bjectiveefficacysafety andremifentanil infusion(TCI)in usingpropofol target—controlled patientsundergoing technique and scheduledforcardiac wereincluded cardiac Omehundred surgery．Methods fiftypatients surgery andmaintainedwith inthis wasinducedwith TCI，remifentanil study．Anesthesia propofol 3-5}tg／kg andremifentanil(2-8 was plasmaconsentration(Cp)ofpropofol propof01 ng／m1)TCI．Calculated at and variableswere titratedtO index(BIS)values50±1 keepbispectral 0．Hemodynamicsrecovery recorded．ResultsA1l remained stable the patients hemodynamicallythroughoutperioperativeperiod awarenessnotnoted．C：onclusionThecombinationof