stimulatory action of cyclooxygenase inhibitors on hematopoiesis a review刺激行动的环氧酶抑制剂在造血审查.pdf

Molecules 2012, 17, 5615-5625; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Stimulatory Action of Cyclooxygenase Inhibitors on Hematopoiesis: A Review Michal Hofer *, Milan Pospíšil, Zuzana Hoferová, Lenka Weiterová and Denisa Komůrková Laboratory of Experimental Hematology, Institute of Biophysics, v.v.i., Academy of Sciences of the Czech Republic, Královopolská 135, CZ-61265 Brno, Czech Republic; E-Mails: ksoucek@ibp.cz (M.P.); hoferovaz@centrum.cz (Z.H.); weiterova@seznam.cz (L.W.); komurkovad@seznam.cz (D.K.) * Author to whom correspondence should be addressed; E-Mail: hofer@ibp.cz; Tel.: +420-541-517-171; Fax: +420-541-211-293. Received: 12 April 2012; in revised form: 4 May 2012 / Accepted: 8 May 2012 / Published: 10 May 2012 Abstract: The presented review summarizes experimental data obtained with a mouse model when investigating the relationship between inhibition of prostaglandin production and hematopoiesis. While prostaglandin E2 acts in a negative feedback control of myelopoiesis, inhibition of cyclooxygenases, responsible for its production, shifts the feedback to positive control. Based on these relationships, agents inhibiting cyclo-oxygenases, known as non-steroidal anti-inflammatory drugs (NSAIDs), can activate hematopoiesis and be protective or curative under myelosuppressive states. The effectiveness of therapeutic use of NSAIDs in these situations is expressive especially under the selective