the chernobyl tissue bank — a repository for biomaterial and data used in integrative and systems biology modeling the human response to radiation切尔诺贝利组织银行u2014u2014存储库中使用的生物材料和数据综合和系统生物学建模人类应对辐射.pdf

Genes 2012, 3, 278-290; doi:10.3390/genes3020278 OPENACCESS genes ISSN 2073-4425 /journal/genes Communication The Chernobyl Tissue Bank — A Repository for Biomaterial and Data Used in Integrative and Systems Biology Modeling the Human Response to Radiation Geraldine Thomas 1,*, Kristian Unger 1, Marko Krznaric 1, Angela Galpine 1, Jackie Bethel 1, 2 2 2 Christopher Tomlinson , Mark Woodbridge and Sarah Butcher 1. Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK; E-Mails: k.unger@imperial.ac.uk (K.U.); m.krznaric@imperial.ac.uk (M.K.); a.galpine@imperial.ac.uk (A.G.); j.bethel@imperial.ac.uk (J.B.) 2. Bioinformatics Support Service, Imperial College London, Sir Ernest Chain Building, Division of Molecular Biosciences, South Kensington Campus, London SW7 2AZ, UK; E-Mails: chris.tomlinson@imperial.ac.uk (C.T.); m.woodbridge@imperial.ac.uk (M.W.); s.butcher@imperial.ac.uk (S.B.) * Author to whom correspondence should be addressed; E-Mail: gerry.thomas@imperial.ac.uk; Tel.: +44-020-8383-2443. Received: 2 April 2012; in revised form: 26 April 2012 / Accepted: 29 April 2012 / Published: 9 May 2012 Abstract: The only unequivocal radiological effect of the Chernobyl accident on human health is the increase in thyroid cancer in those exposed in childhood or early adolescence. In response to the scientific interest in studying the molecular biology of thyroid cancer post Chernobyl, the Chernobyl Tissue